Increased Prevalence of Carpal Tunnel Syndrome in Albright Hereditary Osteodystrophy

Albright hereditary osteodystrophy

Prevalence of carpal tunnel syndrome in motorcyclists.

Carpal tunnel syndrome is prevalent in patients who have a repetitive motion, vibration, or pressure exerted on the wrist joint for an extended period of time. The prevalence of this condition in the general population is approximately 5%. Motorcyclists subject themselves to high levels of vibration from the road and use their wrists to control the motorcycle's brakes, gas intake, and gears via...

Prevalence of Carpal Tunnel Syndrome in Motorcyclists

To the Editor: I enjoyed reading the article " Prevalence of Carpal Tunnel Syndrome in Motorcyclists " by Manes. 1 This article provides insight into a possible new association of symptoms with or the diagnosis for carpal tunnel syndrome due to motorcycle riding. The article makes recommendations for possible risk reduction (ie, prevention), which should be encouraged. However, problems with th...

Heterotopic Ossifications in a Mouse Model of Albright Hereditary Osteodystrophy

Albright hereditary osteodystrophy (AHO) is characterized by short stature, brachydactyly, and often heterotopic ossifications that are typically subcutaneous. Subcutaneous ossifications (SCO) cause considerable morbidity in AHO with no effective treatment. AHO is caused by heterozygous inactivating mutations in those GNAS exons encoding the α-subunit of the stimulatory G protein (Gα(s)). When ...

Germline mosaicism for a GNAS1 mutation and Albright hereditary osteodystrophy.

EDITOR—Albright hereditary osteodystrophy (AHO) is an autosomal dominant disorder characterised by short stature, a round face with a low, flat nasal bridge, brachymetaphalangism, particularly of the fourth and fifth digits, obesity, subcutaneous calcification, and variable degrees of mental retardation. Patients may show end organ resistance to parathyroid hormone (PTH), known as pseudohypopar...